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Special Building Blocks for Help Overcoming Aggregation During Fmoc SPPS

Incorporation of an Hmb protected amino acid into a peptide chain represents one of the most efficient ways of overcoming the effects of aggregation during peptide chain assembly. The effects are long-range, with onset of aggregration often being postponed for as many as six residues. Incorporation of the Hmb derivative can be effected using normal methods of amide-bond formation. Coupling of the following residue is best achieved using the appropriate symmetrical anhydride in DCM. The Hmb group is removed during the course of the standard TFA-mediated cleavage and deprotection reaction.

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