Millipore Sigma Vibrant Logo

Blocking Reagents


ChemiBlock™ Reagents

Request Information

Interactive Product Selector

Find Bulk & Custom Antibodies

Which of the following are you looking for?

Please select a type:

Please choose an option:

ChemiBlock reagents, acquired by us from Chemicon in 2006, are well recognized for their ability to block Human anti-Mouse Antibodies (HAMA) and other HAMA-like agents in patient samples. We are proud to announce the availability of new reinforced reagents designed to minimize interfering antibody effects on immunoassays. These reagents contain proprietary additives that actively combine with interfering antibodies to knock out HAMA, Heterophilic, and other interfering antibodies.

View our scientific poster presented at AACC 2012:
EC50 of reagents used in blocking heterophilic interference in immunoassays

Read our brochure:
Controlling Interfering Antibodies in Diagnostic Assays

For more information on blocking:
Probumin® BSA Products

Active Blocking Reagents
Designed to actively block interfering antibodies (HAAAs, RF, Heterophiles) by neutralizing them allowing the binding of analyte/antigen to capture and detector antibodies to occur. Since active blocking reagents contain specific antibodies they may typically be used in lower concentrations than passive blocking reagents.
Super ChemiBlock Heterophile Blocking Agent Catalogue No. CBS-K
Goat anti-Human IgG Fc Fragment (Gamma Globulin Fraction) Catalogue No. AB728-K
Goat anti-Human IgG Fc Fragment. Affinity purified. (Gamma Globulin Fraction) Catalogue No. AP113-K

Passive Blocking Reagents
Passive blocking reagents are comprised of normal animal immunoglobulins and other components which essentially overwhelm and reduce the concentration of interfering antibodies by providing alternate binding sites to those of the detector and capture antibodies. Passive blocking reagents may be combined and/or used with active blockers to optimize formulations for specific assays.
ChemiBlock II Heterophile Blocking Agent Catalogue No. CBII-K
Mouse IgG (Purified) Catalogue No. PP54-K
Rabbit IgG (Gamma Globulin Fraction) Catalogue No. PP63-K
Rabbit IgG (Purified) Catalogue No. PP64-K
Equine IgG (Gamma Globulin Fraction) Catalogue No. PP301-K

Isotype Specific Mouse IgG
Purified Mouse IgG1. Affinity purified. Catalogue No. PP100-K
ChemiBlock Blend Heterophile Blocking Agent. Affinity purified. Catalogue No. PP1230-K

Eliminate False Positives with ChemiBlock Reagents

Clinical Laboratory Reagent Water Systems

Complete Solutions for Blood Typing Monoclonal Antibodies video

Watch the Video