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Increase Volatility, Sensitivity and Detectibility

For analysis by gas chromatography, many samples, such as readily decomposed substances or those with low volatility, can only be investigated after their conversion to stable, volatile derivatives. Besides increasing sample volatility, derivatization reactions also improve the sensitivity of detection and enhance detectibility.

MilliporeSigma offers a high-quality range of acylating, alkylating and silylating derivatization reagents, as well as several ancillary reagents. The following table provides an overview of the application fields of our derivatization reagents.

Application Fields

Derivatisation ReagentSample Type
AlcoholsAminesCarboxylic Acids
Bis(trimethylsilyl) acetamide
Bis(trimethyl) trifluoroacetamide
Heptafluorobutyric anhydride -
Hexamethyldisilazane -
N-Methyl-bis(trifluoroacetamide) -
N-Methyl-N-(trimethylsilyl)-trifluoro acetamide - - -
Trifluoroacetic anhydride -
N-(Trimethylsilyl) acetamide
N-(Trimethylsilyl) diethylamine -
N-(Trimethylsilyl) imidazole -
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