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L1 US Pharmacopoeia Columns

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LiChrospher® RP-18 (5 µm) HPLC Columns

LiChrospher® HPLC columnsMilliporeSigma offers a broad range of HPLC columns that are fully compliant with USP (United States Pharmacopoeia) specifications. L1 USP columns are described as octadecyl silane, chemically linked to porous silica or ceramic micro particles. Our high-quality L1 USP products deliver reliable, reproducible results – time after time. A perfect example is: LiChrospher® RP-18 (5 µm).

Reliability Meets Versatility

LiChrospher® 100 RP-18 HPLC columns are incredibly reliable and highly versatile. These traditionally manufactured spherical silica based supports are designed for reversed-phase chromatography of acidic, neutral and weakly basic compounds – substances frequently found in all analytical fields. The columns’ optimal selectivity and performance ensure that these parameters remain constant from batch to batch and from year to year. Furthermore, the difference in polarities is clearly described by the selectivity pattern. As a result, LiChrospher® 100 RP-18 allows faster, more accurate method development.

Features and Benefits

  • Classified as L1 USP column
  • Suitable for acidic, neutral and weakly basic compounds
  • Optimal column selectivity and performance
  • Reproducible results due to excellent batch-to-batch consistency 
  • Enable faster, more accurate method development


Application Example

Pharmaceutical analysis: Acetyl salicylic acid. Learn More

Pharmaceutical analysis: 2-Oxoacids. Learn More

Pharmaceutical analysis: Corticoids. Learn More

Environmental analysis: Naphthols, chlorophenol and nitro aromatics in water. Learn More

Product Range

LiChroCART® Stainless Steel Cartridges

The LiChroCART® columns (75, 125, 150, and 250 mm length) with an i.d of 3 and 4 mm require a manu-CART® NT cartridge column holder, which can be used to hold one cartridge column with or without a 4×4 mm guard column. 250-10 mm LiChroCART® columns require the manu-CART® “10”-II cartridge holder.

Hibar® Stainless Steel Columns

Hibar® columns are supplied complete with endfittings. When using a guard column with a Hibar® column, we recommend a guard column cartridge holder for 4×4 mm LiChroCART® guard column cartridges.

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