Millipore Sigma Vibrant Logo

L1 US Pharmacopoeia Columns

Request Information

LiChrosorb® RP-18 (5 µm) HPLC Columns and Sorbents

LiChrosorb® HPLC packing materialsMilliporeSigma offers a broad range of HPLC columns that are fully compliant with USP (United States Pharmacopoeia) specifications. L1 USP columns are described as octadecyl silane, chemically linked to porous silica or ceramic micro particles. Our high-quality L1 USP products deliver reliable, reproducible results – time after time. A perfect example is: LiChrosorb® RP-18 (5 µm).

Packing Materials for a Successful Start

LiChrosorb® is one of the most successful HPLC packing materials on the market. Its use in thousands of chromatography applications has been documented for more than 35 years. The totally porous irregular particles of LiChrosorb® RP-18 (5 µm) are made of silica with an octadecyl derivative. This highly reliable sorbent is suitable for reversed-phase HPLC of neutral, acidic and weak basic compounds, according to L1 USP specifications.

Analytical or Semi-Preparative? You Choose.

LiChrosorb® RP-18 (5 µm) sorbents can be packed in various columns and cartridges upon request. For analytical use, we offer LiChroCART® cartridges and Hibar® RT columns in 125x4 or 250x4 mm dimensions. Alternatively, 250x10 mm versions are available for semi-preparative applications.

Features and Benefits

  • Classified as L1 USP column
  • Reversed-phase HPLC of neutral, acidic and weak basic compounds
  • Totally porous irregular particles for reliable results
  • Column options for greater flexibility

Product Range

LiChroCART® Stainless Steel Cartridges

The LiChroCART® columns (125 and 250 mm length, 4 mm i.d.) require a manu-CART® NT cartridge column holder, which can be used to hold one cartridge column with or without a 4×4 mm guard column.

Hibar® Stainless Steel Columns

Hibar® columns are supplied complete with endfittings. When using a guard column with a Hibar® column, we recommend a guard column cartridge holder for 4×4 mm LiChroCART® guard column cartridges.

Specifications LiChrosorb® RP-18

Sorbent characteristics
Irregular particles of silica with octadecyl derivative, suitable for reversed-phase chromatography and the separation of neutral, acidic and weak basic compounds
Particle size 5; 7; 10
Pore volume 1.0 mL/g
Spec. surface area 300 m2/g
Carbon load 16.2 % C
Coverage of the surface 3.0 μmol/m2
Application Notes Finder
Search for chromatography applications by analyte, column type, detection method, sorbent type or any other search term:
Chromatography Application World

Application World

The ultimate source for the latest news in your field

Learn More
Education, support, and events

Education, Support & Events: All the resources you need to succeed.

Learn More