525145 sPLA₂-IIA Inhibitor I - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₄₁H₅₀N₈O₆ · CF₃CO₂H

Pricing & Availability

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525145-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA2-IIA (human type IIA secreted phospholipase A2; IC50 = 12.8 μM). Shown to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA even at 10 μM concentration.
      Catalogue Number525145
      Brand Family Calbiochem®
      Synonymsc(2NapA)LS(2NapA)R, TFA
      References
      ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
      Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetsPLA2-IIA (human type IIA secreted phospholipase A2
      Primary Target IC<sub>50</sub>12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      sPLA₂-IIA Inhibitor I - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      sPLA₂-IIA Inhibitor I - Calbiochem Certificates of Analysis

      TitleLot Number
      525145

      References

      Reference overview
      Church, W.B., et al. 2001. J. Biol. Chem. 276, 33156.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-August-2008 RFH
      Synonymsc(2NapA)LS(2NapA)R, TFA
      DescriptionA highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A2 (sPLA2-IIA) (IC50 = 12.8 µM). Reported to effectively block sPLA2-IIA-induced PGE2 production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 µM. Does not have any significant effect on the activities of porcine sPLA2-IB, Naja naja sPLA2-IB, or Crotalus durissus sPLA2-IIA at 10 µM.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₁H₅₀N₈O₆ · CF₃CO₂H
      Peptide Sequencecyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesChurch, W.B., et al. 2001. J. Biol. Chem. 276, 33156.