475957 c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₂N₄O₃ 413611-93-5

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475957-10MG
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      10 mg
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      Description
      OverviewA cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa residues 363 and 381 (KD = 4.4 µM), while 10058-F4 interaction site is located within aa residues 402 through 412 (KD = 13 µM).
      Catalogue Number475957
      Brand Family Calbiochem®
      Synonyms7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamine, 10074-G5
      References
      ReferencesFollis, A.V., et al. 2008. Chem. Biol. 15, 1149.
      Yin, X., et al. 2003. Oncogene 22, 6151.

      Sold under license of U.S. Patent 7,026,343.
      Product Information
      CAS number413611-93-5
      FormDeep orange solid
      Hill FormulaC₁₈H₁₂N₄O₃
      Chemical formulaC₁₈H₁₂N₄O₃
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      475957

      References

      Reference overview
      Follis, A.V., et al. 2008. Chem. Biol. 15, 1149.
      Yin, X., et al. 2003. Oncogene 22, 6151.

      Sold under license of U.S. Patent 7,026,343.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2010 RFH
      Synonyms7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamine, 10074-G5
      DescriptionA cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa 363 and 381 (KD = 4.4 µM), while 10058-F4 interaction site is located within aa residues 402 through 412 (KD = 13 µM).
      FormDeep orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number413611-93-5
      Chemical formulaC₁₈H₁₂N₄O₃
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFollis, A.V., et al. 2008. Chem. Biol. 15, 1149.
      Yin, X., et al. 2003. Oncogene 22, 6151.

      Sold under license of U.S. Patent 7,026,343.