448105 c-Met Kinase Inhibitor III - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₁H₁₇Cl₂FN₂O₂

Pricing & Availability

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448105-2MG
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      2 mg
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      Description
      OverviewA 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC50 = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC50 = 93 nM) and displays HDG-dependent anti-proliferative activity (IC50 = 300 nM) in HUVEC cultures, in vitro.
      Catalogue Number448105
      Brand Family Calbiochem®
      Synonyms2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
      References
      ReferencesNishii, H., et al. 2009. Bioorg. Med. Chem. Lett. 20, 1405.
      Product Information
      FormWhite solid
      Hill FormulaC₂₁H₁₇Cl₂FN₂O₂
      Chemical formulaC₂₁H₁₇Cl₂FN₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HLPC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      c-Met Kinase Inhibitor III - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      c-Met Kinase Inhibitor III - Calbiochem Certificates of Analysis

      TitleLot Number
      448105

      References

      Reference overview
      Nishii, H., et al. 2009. Bioorg. Med. Chem. Lett. 20, 1405.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-February-2011 RFH
      Synonyms2-(6-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)quinolin-3-yl)cyclopropanecarboxamide
      DescriptionA 6-Benzyloxyquinoline derivative which acts as an ATP-competitive inhibitor against c-Met (IC50 = 9.3 nM), with more than 20 fold selectivity against a panel of 19 receptor tyrosine kinases and 8 serine/threonine kinases, in enzymatic assays. Also exhibits MKN45 cell growth inhibition (IC50 = 93 nM) and displays HDG-dependent anti-proliferative activity (IC50 = 300 nM) in HUVEC cultures, in vitro.
      FormWhite solid
      Chemical formulaC₂₁H₁₇Cl₂FN₂O₂
      Structure formulaStructure formula
      Purity≥95% by HLPC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesNishii, H., et al. 2009. Bioorg. Med. Chem. Lett. 20, 1405.