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504597 YM298198 Hydrochloride - CAS 748758-45-4 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride

Primary Target: mGlu₁ receptors
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      Overview

      Replacement Information

      Key Specifications Table

      CAS #Empirical Formula
      748758-45-4C₁₈H₂₂N₄OS•HCl
      Description
      OverviewA highly potent antagonist selective for mGlu1 receptors (IC50 = 16 nM). Biologically active admitted orally or systematically. Often used in assessing the functional roles of mGlu1 receptors in a variety of research areas, such as anxiety and stress related disorders, analgesia, nociceptive pain, and schizophrenia.
      Catalogue Number504597
      Brand Family Calbiochem®
      Synonyms6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
      References
      ReferencesHerman, J., et al. 2012. Novel Antischizophrenia Treatments. Springer Berlin Heidelberg, 2012. 297.
      Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 99.
      Fukunaga, I., et al. 2007. Brit. J. Pharmacol. 151, 870.
      Knöpfel, T. 2007. Brit. J. Pharmacol. 151, 723.
      Kohara, A., et al. 2005. J. Pharmacol. & Exp. Therap. 315, 163.
      Product Information
      CAS number748758-45-4
      FormCream solid
      Hill FormulaC₁₈H₂₂N₄OS•HCl
      Chemical formulaC₁₈H₂₂N₄OS•HCl
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetmGlu₁ receptors
      Primary Target IC<sub>50</sub>16 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      504597

      Documentation

      YM298198 Hydrochloride - CAS 748758-45-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Herman, J., et al. 2012. Novel Antischizophrenia Treatments. Springer Berlin Heidelberg, 2012. 297.
      Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 99.
      Fukunaga, I., et al. 2007. Brit. J. Pharmacol. 151, 870.
      Knöpfel, T. 2007. Brit. J. Pharmacol. 151, 723.
      Kohara, A., et al. 2005. J. Pharmacol. & Exp. Therap. 315, 163.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms6-Amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide hydrochloride
      DescriptionA highly potent antagonist selective for mGlu1 receptors (IC50 = 16 nM). Biologically active admitted orally or systematically. Often used in assessing the functional roles of mGlu1 receptors in a variety of research areas, such as anxiety and stress related disorders, analgesia, nociceptive pain, and schizophrenia.
      FormCream solid
      CAS number748758-45-4
      Chemical formulaC₁₈H₂₂N₄OS•HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHerman, J., et al. 2012. Novel Antischizophrenia Treatments. Springer Berlin Heidelberg, 2012. 297.
      Hikichi, H., et al. 2010. Eur. J. Pharmacol. 639, 99.
      Fukunaga, I., et al. 2007. Brit. J. Pharmacol. 151, 870.
      Knöpfel, T. 2007. Brit. J. Pharmacol. 151, 723.
      Kohara, A., et al. 2005. J. Pharmacol. & Exp. Therap. 315, 163.