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681664 Wnt Agonist I in DMSO - CAS 853220-52-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₉H₁₈N₄O₃ 853220-52-7

Pricing & Availability

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681664-2MG
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      Glass bottle 2 mg
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      Description
      OverviewA cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.
      Catalogue Number681664
      Brand Family Calbiochem®
      Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I in DMSO
      References
      ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
      Product Information
      CAS number853220-52-7
      FormLiquid
      FormulationA 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO.
      Hill FormulaC₁₉H₁₈N₄O₃
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Wnt Agonist I in DMSO - CAS 853220-52-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Wnt Agonist I in DMSO - CAS 853220-52-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      681664

      References

      Reference overview
      Liu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2012 JSW
      Synonyms2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine, Wnt Pathway Activator I in DMSO
      DescriptionA cell-permeable, potent, and selective activator of Wnt signaling that does not inhibit the activity of GSK-3β (IC50 >60 µM). Shown to mimic the effect of Wnt and induce β-catenin and TCF (T-cell fate)-dependent transcriptional activity (EC50 = 700 nM in HEK-293T cells). Reported to cause substantial head defects during Xenopus embryonic development. The solid form of this compound (Cat. No. 681665) is also available.
      FormLiquid
      FormulationA 25 mM (2 mg/228 µL) solution of Wnt Agonist I (Cat. No. 681665) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number853220-52-7
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage ≤ -70°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Toxicity Irritant
      ReferencesLiu, J., et al. 2005. Angew. Chem. Int. Ed. 44, 1987.