681635 W-12, Hydrochloride - CAS 89108-46-3 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₄H₁₈N₂O₂S · HCl 89108-46-3

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
681635-1MG
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Plastic ampoule 1 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 300 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM).
      Catalogue Number681635
      Brand Family Calbiochem®
      SynonymsN-(4-Aminobutyl)-2-naphthalenesulfonamide, HCl
      References
      ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Product Information
      CAS number89108-46-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₄H₁₈N₂O₂S · HCl
      Chemical formulaC₁₄H₁₈N₂O₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMyosin light chain kinase (Mlck)
      Primary Target IC<sub>50</sub>300 µM and 260 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      W-12, Hydrochloride - CAS 89108-46-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      W-12, Hydrochloride - CAS 89108-46-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      681635

      References

      Reference overview
      Tanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-January-2010 RFH
      SynonymsN-(4-Aminobutyl)-2-naphthalenesulfonamide, HCl
      DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 260 µM) and myosin light chain kinase (IC50 = 300 µM).
      FormWhite solid
      CAS number89108-46-3
      Chemical formulaC₁₄H₁₈N₂O₂S · HCl
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityEthanol (5 mg/ml) or H₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

      Related Products & Applications

      Related Products

      Catalog Number Description  
      681625 W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem Show Pricing & Availability
      681629 W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem Show Pricing & Availability
      681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Show Pricing & Availability

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors