532628 Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem

532628
View Pricing & Availability

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₁H₂₄ClN₇O 1383716-33-3

Pricing & Availability

Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
5.32628.0001
Retrieving availability...
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 5 mg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity needs to be mulitiple of
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number532628
      Brand Family Calbiochem®
      Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
      References
      ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.
      Product Information
      CAS number1383716-33-3
      FormWhite powder
      Hill FormulaC₂₁H₂₄ClN₇O
      Chemical formulaC₂₁H₂₄ClN₇O
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVps34
      Primary Target IC<sub>50</sub>25 nM using recombinant Vsp34:Vps15 complex
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Vps34 Inhibitor, VPS34-IN1 - CAS 1383716-33-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Bago, R., et al. 2014. Biochem. J. 463, 413.

      Technical Info

      Title
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage. (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-April-2015 JSW
      Synonyms1-(2-(2-Chloropyridin-4-ylamino)-4ʹ-(cyclopropylmethyl)-4,5ʹ-bipyrimidin-2ʹ-ylamino)-2-methylpropan-2-ol, Vacuolar Protein Sorting 34 Inhibitor, PIK3C3 Inhibitor
      DescriptionA cell-permeable pyridinylaminobipyrimidinylamino compound that acts as a highly potent, selective, and reversible inhibitor of Vps34 activity (IC50 = 25 nM using recombinant Vsp34:Vps15 complex). Displays excellent selectivity over 340 other protein kinases and 25 lipid kinases (even at ~ 1 µM), including class I and class II PI 3-kinases. Does not affect Ser473 or Thr308 phosphorylation status of Akt. Suppresses endosomal localization of GFP-2xFYVEHrs (IC50 = 100 nM) in U2OS cells. Rapidly inhibits SGK3 activity in a dose-dependent manner (~40% inhibition at 100 nM) and causes a diminution in T-loop and hydrophobic motif phosphorylation.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1383716-33-3
      Chemical formulaC₂₁H₂₄ClN₇O
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBago, R., et al. 2014. Biochem. J. 463, 413.