676493 VEGF Inhibitor, Flt₂₋₁₁ - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₆₁H₁₀₄N₁₄O₁₅

Pricing & Availability

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676493-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewAn 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is shown to inhibit angiogenesis in chick chorioallantoic membrane and inhibits VEGF-induced vascular permeability. Neither binds to vascular endothelial growth factor (VEGF) nor inhibits its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
      Catalogue Number676493
      Brand Family Calbiochem®
      SynonymsNITVTLKKFPL, VEGFR Tyrosine Kinase Inhibitor X, VEGFR1 Kinase Inhibitor I
      References
      ReferencesTan, D.C., et al. 2001. FEBS Lett. 494, 150.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,200,954.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₁H₁₀₄N₁₄O₁₅
      Chemical formulaC₆₁H₁₀₄N₁₄O₁₅
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetVEGF
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      VEGF Inhibitor, Flt₂₋₁₁ - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      VEGF Inhibitor, Flt₂₋₁₁ - Calbiochem Certificates of Analysis

      TitleLot Number
      676493

      References

      Reference overview
      Tan, D.C., et al. 2001. FEBS Lett. 494, 150.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      SynonymsNITVTLKKFPL, VEGFR Tyrosine Kinase Inhibitor X, VEGFR1 Kinase Inhibitor I
      DescriptionAn 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is reported to inhibit angiogenesis in chick chorioallantoic membrane and VEGF-induced vascular permeability. Does not bind to vascular endothelial growth factor (VEGF) nor inhibit its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₁H₁₀₄N₁₄O₁₅
      Peptide SequenceH-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or acetonitrile (20%)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTan, D.C., et al. 2001. FEBS Lett. 494, 150.