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672999 V-ATPase Inhibitor, KM91104 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₄H₁₂N₂O₄

Pricing & Availability

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672999-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 of 2.3 µM), in vitro. It is also shown to inhibit osteoclast resorption (IC50 of 1.2 µM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.
      Catalogue Number672999
      Brand Family Calbiochem®
      SynonymsH+-ATPase Inhibitor
      References
      ReferencesKartner, N., et al. 2010. J. Biol. Chem. 285, 37476.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₄H₁₂N₂O₄
      Chemical formulaC₁₄H₁₂N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      V-ATPase Inhibitor, KM91104 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      V-ATPase Inhibitor, KM91104 - Calbiochem Certificates of Analysis

      TitleLot Number
      672999

      References

      Reference overview
      Kartner, N., et al. 2010. J. Biol. Chem. 285, 37476.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2015 JSW
      SynonymsH+-ATPase Inhibitor
      DescriptionA cell-permeable, non-macrolide small molecule V-ATPase inhibitor that specifically targets the a3-b2 subunit protein protein interation of V-ATPase (IC50 of 2.3 µM), in vitro. It is also shown to inhibit osteoclast resorption (IC50 of 1.2 µM) on both synthetic hydroxyapatite surfaces and dentin slices in an in vitro osteoclast model, RANKL-differentiated RAW 264.7 cells, without significantly affecting RAW 264.7 cell viability or RANKL-mediated osteoclast differentiation.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₁₂N₂O₄
      Structure formulaStructure formula
      Purity>98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKartner, N., et al. 2010. J. Biol. Chem. 285, 37476.