662088 UCH-L1 Inhibitor II - CAS 439946-22-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₅H₁₀N₂O₄S 439946-22-2

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662088-10MG
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      Plastic ampoule 10 mg
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      Description
      OverviewA thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
      Catalogue Number662088
      Brand Family Calbiochem®
      SynonymsUbiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946
      References
      ReferencesMermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3729.
      Product Information
      CAS number439946-22-2
      FormBrown solid
      Hill FormulaC₁₅H₁₀N₂O₄S
      Chemical formulaC₁₅H₁₀N₂O₄S
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥85% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      UCH-L1 Inhibitor II - CAS 439946-22-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      UCH-L1 Inhibitor II - CAS 439946-22-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      662088

      References

      Reference overview
      Mermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3729.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsUbiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946
      DescriptionA thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number439946-22-2
      Chemical formulaC₁₅H₁₀N₂O₄S
      Structure formulaStructure formula
      Purity≥85% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett. 17, 3729.