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534380 UBLCP1 Inhibitor - Calbiochem

A potent, selective, reversible & cell active UBLCP1 inhibitor (IC₅₀ = 500 nM). Enhances nuclear proteasome activity in HaCaT & HEK293T cells at 2.5 µM.

UBLCP1 Inhibitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-((1-(Cyclohexylamino)-1-oxohexan-2-yl)oxy)-2-hydroxy-5-((2-(trifluoromethoxy)phenyl)ethynyl)benzoic acid, Ubiquitin-like Domain-containing C-terminal domain Phosphatase 1 Inhibitor

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534380
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      Description
      OverviewA cell-permeable salicylic acid based compound that acts as a potent, reversible and pNPP-competitive inhibitor of UBLCP1 activity (IC50 = 500 nM; Ki = 1 µM). Shown to occupy the active site and the adjacent binding pocket. Displays moderate to excellent selectivity (5- to >50-fold) over 19-other phosphatases. Significantly enhances the nuclear proteasome activity at 2.5 µM in HaCaT & HEK293T cells.

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number534380
      Brand Family Calbiochem®
      Synonyms4-((1-(Cyclohexylamino)-1-oxohexan-2-yl)oxy)-2-hydroxy-5-((2-(trifluoromethoxy)phenyl)ethynyl)benzoic acid, Ubiquitin-like Domain-containing C-terminal domain Phosphatase 1 Inhibitor
      DescriptionUBLCP1 Inhibitor
      References
      ReferencesHe, Y., et al. 2015. Bioorg. Med. Chem. 23, 2798.
      Product Information
      FormWhite solid
      Hill FormulaC₂₈H₃₀F₃NO₆
      Chemical formulaC₂₈H₃₀F₃NO₆
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetUBLCP1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Identification Number
      Catalog Number GTIN
      5.34380.00014054839117183

      Documentation

      UBLCP1 Inhibitor - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      He, Y., et al. 2015. Bioorg. Med. Chem. 23, 2798.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-September-2016 JSW
      Synonyms4-((1-(Cyclohexylamino)-1-oxohexan-2-yl)oxy)-2-hydroxy-5-((2-(trifluoromethoxy)phenyl)ethynyl)benzoic acid, Ubiquitin-like Domain-containing C-terminal domain Phosphatase 1 Inhibitor
      DescriptionA cell-permeable salicylic acid based compound that acts as a potent, reversible and pNPP-competitive inhibitor of UBLCP1 activity (IC50 = 500 nM; Ki = 1 µM). Shown to occupy the active site and the adjacent binding pocket. Displays moderate to excellent selectivity (5- to >50-fold) over 19-other phosphatases. Significantly enhances the nuclear proteasome activity at 2.5 µM in HaCaT & HEK293T cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₃₀F₃NO₆
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHe, Y., et al. 2015. Bioorg. Med. Chem. 23, 2798.