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648485 TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem

648485
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Empirical FormulaCAS #
C₁₈H₂₁N₅O₃ 349085-38-7

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648485-10MG
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      Description
      OverviewA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
      Catalogue Number648485
      Brand Family Calbiochem®
      SynonymsHC-030031
      References
      ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
      Product Information
      CAS number349085-38-7
      FormWhite solid
      Hill FormulaC₁₈H₂₁N₅O₃
      Chemical formulaC₁₈H₂₁N₅O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TrpA1 Antagonist, HC-030031 - CAS 349085-38-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      648485

      References

      Reference overview
      Taylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2012 JSW
      SynonymsHC-030031
      DescriptionA cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number349085-38-7
      Chemical formulaC₁₈H₂₁N₅O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTaylor-Clark, T., et al. 2008. Mol. Pharmacol. 73, 274.
      McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A. 104, 13525.