645900 Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

645900
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₄O₆ 38748-32-2

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      645900-1MG
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          Plastic ampoule 1 mg
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          645900-5MG
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              Description
              OverviewA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-α-induced apoptosis, and inhibits TNF-α-induced activation of NF-κB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
              Catalogue Number645900
              Brand Family Calbiochem®
              SynonymsPG490
              References
              ReferencesZhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
              Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
              Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
              Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
              Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
              Yang, Y., et al. 1998. Immunopharmacology 40, 139.
              Product Information
              CAS number38748-32-2
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₂₀H₂₄O₆
              Chemical formulaC₂₀H₂₄O₆
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetActivate DEVD-cleaving caspases
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSYK7751000
              Safety Information
              R PhraseR: 20/21/22-40

              Harmful by inhalation, in contact with skin and if swallowed.
              Limited evidence of a carcinogenic effect.
              S PhraseS: 22-36

              Do not breathe dust.
              Wear suitable protective clothing.
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Harmful & Carcinogenic / Teratogenic
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem SDS

              Title

              Safety Data Sheet (SDS) 

              Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem Certificates of Analysis

              TitleLot Number
              645900

              References

              Reference overview
              Zhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
              Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
              Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
              Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
              Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
              Yang, Y., et al. 1998. Immunopharmacology 40, 139.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision08-May-2009 RFH
              SynonymsPG490
              DescriptionA novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-α-induced activation of NF-κB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-κB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases.
              FormOff-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number38748-32-2
              RTECSYK7751000
              Chemical formulaC₂₀H₂₄O₆
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (20 mg/ml)
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
              Toxicity Harmful & Carcinogenic / Teratogenic
              ReferencesZhao, Q., et al. 2005. J. Biol. Chem. 280, 8101.
              Shepherd, E., et al. 2004. J. Biol. Chem. 279, 54023.
              Chan, M.A., et al. 1999. Phytother. Res. 13, 464.
              Lee, K.Y., et al. 1999. J. Biol. Chem. 274, 13451.
              Qiu, D., et al. 1999. J. Biol. Chem. 274, 13443.
              Yang, Y., et al. 1998. Immunopharmacology 40, 139.