647925 Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₇H₂₂N₂O₃ 58880-19-6

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647925-1MG
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      Plastic ampoule 1 mg
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      Description
      OverviewA potent and reversible, cell-permeable inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-transformed NIH/3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. Down-regulates p57kip2 in Hep 3B cells. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A. 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647926) in DMSO is also available.
      Catalogue Number647925
      Brand Family Calbiochem®
      Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
      References
      ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
      Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
      Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
      Taunton, J., et al. 1996. Science 272, 408.
      Futamura, M., et al. 1995. Oncogene 10, 1119.
      Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
      Product Information
      CAS number58880-19-6
      ATP CompetitiveN
      FormOff-white lyophilized solid
      Hill FormulaC₁₇H₂₂N₂O₃
      Chemical formulaC₁₇H₂₂N₂O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationTrichostatin A, Streptomyces sp., CAS 58880-19-6, is a cell-permeable, potent, reversible inhibitor of histone deacetylase (IC50 = 6, 38, and 6 nM for HDAC1, 4, and 6, respectively).
      Biological Information
      Primary Targethistone deactylase
      Primary Target IC<sub>50</sub>73 nM inhibiting IL-2 gene expressionin Jurkat cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMI5215000
      Safety Information
      R PhraseR: 20/21/22-36/37/38-43

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      May cause sensitization by skin contact.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Trichostatin A, Streptomyces sp. - CAS 58880-19-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      647925

      References

      Reference overview
      Furumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
      Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
      Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
      Taunton, J., et al. 1996. Science 272, 408.
      Futamura, M., et al. 1995. Oncogene 10, 1119.
      Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.

      Brochure

      Title
      Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling (EMD)

      Technical Info

      Title
      White Paper - The Message in the Marks: Deciphering Cancer Epigenetics (EMD)

      Citations

      Title
    • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2016 JSW
      Synonyms4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, TSA, HDAC Inhibitor IX
      DescriptionA potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC50 = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model. IC50 = 6 nM for HDAC1; 38 nM for HDAC4, and 8.6 nM for HDAC6A.
      FormOff-white lyophilized solid
      CAS number58880-19-6
      RTECSMI5215000
      Chemical formulaC₁₇H₂₂N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml), ethanol (1 mg/ml), or methanol
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Following reconstitution in ethanol, refrigerate (4°C). DMSO stock solutions are stable for up to 6 months at -20°C. Ethanol stock solutions are stable for up to 3 months at 4°C.
      Toxicity Harmful
      ReferencesFurumai, R., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 87.
      Gray, S.G. and Ekstrom, T.J. 1998. Biochem. Biophys. Res. Commun. 245, 423.
      Takahashi, I., et al. 1996. J. Antibiot. 49, 453.
      Taunton, J., et al. 1996. Science 272, 408.
      Futamura, M., et al. 1995. Oncogene 10, 1119.
      Hoshikawa, Y., et al. 1994. Exp. Cell Res. 214, 189.
      Citation
    • Qiou Wei, W. Keith Miskimins and Robin Miskimins. (2005) Stage-specific expression of myelin basic protein in oligodendrocytes involves NKX2.2-mediated repression that is relieved by the Sp1 transcription factor. Journal of Biological Chemistry 280, 16284-16294.