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|616431-500MG||Glass bottle||500 mg||
|Overview||A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities, respectively, of MAO A/B (Ki = 101.9 and 16.0 µM, respectively) and LSD1/2 (Ki = 242.7 and 180.0 µM, respectively), four members of a flavin-dependent amine oxidase family enzymes, by a covalent adduct formation with the enzyme-bound FAD. In addition to preventing LSD1-CoREST (Corepressor of RE1-Silencing Transcription factor) complex-mediated H3K4 demethylation (IC50 < 2 µM), TCP also inhibits LSD1-HCF-1 (Host Cell Factor-1) complex-mediated H3K9 demethylase activity, which is demonstrated to be an essential mechanism for the replication and latent infection of the α-herpesviruses HSV and VZV. The combined treatment of 2 µM TCP and 10 µM CHIR99061 (Cat. No. 361559) is reported to enable the reprogramming of Oct4/Klf4-transduced primary HNEKs (Human Neonatal Epidermal Keratinocytes) into iPS (induced Pluripotent Stem) cells, albeit at a 100-time lower efficiency as seen in cultures transduced with 4-TFs (Oct44, Klf4, Sox2, and c-Myc).|
|Synonyms||Histone Lysine Demethylase Inhibitor I, LSD Inhibitor V, Monoamine Oxidase Inhibitor I, Parnate, 2-PCPA, TCP, (1R)-2-Phenylcyclopropan-1-amine, HCl, trans-2-Phenylcyclopropylamine, HCl, BHC110 Inhibitor V, LSD2 Inhibitor I, MOA Inhibitor I, KDM1 Inhibitor V, LSD1 Inhibitor V|
|Hill Formula||C₉H₁₁N •HCl|
|Chemical formula||C₉H₁₁N •HCl|
|Structure formula Image|
|Purity||≥97% by NMR|
|Safety Information according to GHS|
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
Tranylcypromine, HCl - CAS 1986-47-6 - Calbiochem SDS
|Liang, Y., et al. 2009. Nat. Med. 15, 1312.
Li, W., et al. 2009. Stem Cells 27, 2992.
Karytinos, A., et al. 2009. J. Biol. Chem. 284, 17775.
Hruschka, S., et al. 2008. Bioorg. Med. Chem. 16, 7148.
Schmidt, D.M., and McCafferty, D.G. 2007. Biochemistry 46, 4408.
Lee, M.G., et al. 2006. Chem. Biol. 13, 563.
Yoshida, S., et al. 2004. Bioorg. Med. Chem. 12, 2645.
|White Paper - The Message in the Marks: Deciphering Cancer Epigenetics|
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