616377 Sigma-AldrichToxin B, Clostridium difficile - Calbiochem
A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue.
More>> A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Cytotoxin
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Overview
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Key Specifications Table
Pricing & Availability
Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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616377-2UG |
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Plastic ampoule | 2 μg |
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Description | |
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Overview | A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositiol 4,5-bisphosphate. May also block serotonin release, and stimulate the production of phospholipases C and D. Due to its ability to affect depolymerization of the cytoskeleton, toxin B has been shown to inhibit biphasic muscle contraction. Unlike Exoenzyme C3 (Cat. No. 341208), this toxin does not require assistance to permeabilize cells. |
Catalogue Number | 616377 |
Brand Family | Calbiochem® |
Synonyms | Cytotoxin |
Product Information | |
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ATP Competitive | N |
Form | Lyophilized |
Formulation | Lyophilized from 50 mM Tris, 50 mM NaCl, 0.1% trehalose, pH 7.5. |
Reversible | N |
Quality Level | MQ100 |
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Physicochemical Information | |
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Cell permeable | N |
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Safety Information according to GHS | |
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RTECS | XW5807300 |
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Specifications |
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Documentation
Toxin B, Clostridium difficile - Calbiochem Certificates of Analysis
Title | Lot Number |
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616377 |
References
Reference overview |
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Mackay, D.J. and Hall, A. 1998. J. Biol. Chem. 273, 20685. Prepens, U., et al. 1996. J. Biol. Chem. 271, 7324. Schmidt, M., et al. 1996. Eur. J. Biochem. 240, 707. Wilkins, T.D. and Lyerly, D.M. 1996. Trends Microbiol. 4, 49. |