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605225 Thrombospondin, Human Platelets

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605225
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605225-25UG
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      Plastic ampoule 25 μg
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      Description
      OverviewNative thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by α-thrombin. An angiogenesis inhibitor that blocks the FGF-induced neovascularization of the rat cornea. An inducer of platelet aggregation. Synthesized by a number of different cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.
      Catalogue Number605225
      Brand Family Calbiochem®
      References
      ReferencesArmstrong, L.C., et al. 2002. Mol. Biol. Cell 13, 1893.
      Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
      Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
      Koch, A.E., et al. 1993. Pathobiology 61, 1.
      Tolsma, S.S., et al. 1993. J. Cell Biol. 122, 497.
      Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
      Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
      Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6624.
      Product Information
      FormLyophlized
      FormulationLyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Thrombospondin, Human Platelets SDS

      Title

      Safety Data Sheet (SDS) 

      Thrombospondin, Human Platelets Certificates of Analysis

      TitleLot Number
      605225

      References

      Reference overview
      Armstrong, L.C., et al. 2002. Mol. Biol. Cell 13, 1893.
      Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
      Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
      Koch, A.E., et al. 1993. Pathobiology 61, 1.
      Tolsma, S.S., et al. 1993. J. Cell Biol. 122, 497.
      Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
      Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
      Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6624.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2008 RFH
      DescriptionNative thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by a-thrombin. Inhibits FGF-induced neovascularization on rat cornea. An inducer of platelet aggregation. Synthesized by a number of cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.
      FormLyophlized
      FormulationLyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.
      SourcePrepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      SolubilityH₂O. Please refer to lot-specific reconstitution volume on the vial label.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.
      Toxicity Standard Handling
      Merck USA index14 9387
      ReferencesArmstrong, L.C., et al. 2002. Mol. Biol. Cell 13, 1893.
      Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
      Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
      Koch, A.E., et al. 1993. Pathobiology 61, 1.
      Tolsma, S.S., et al. 1993. J. Cell Biol. 122, 497.
      Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
      Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
      Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 6624.