582243 Tetanus Toxin, Clostridium tetani - Calbiochem

Overview

Replacement Information

Key Specifications Table

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Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
582243-25UG
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      Description
      OverviewProduced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
      Catalogue Number582243
      Brand Family Calbiochem®
      References
      ReferencesMontecucco, C., et al. 1994. FEBS Lett. 346, 92.
      Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityBinds GT1b ganglioside in a hemagglutination assay
      Primary TargetTetanus toxin is one of the deadliest toxins known
      PuritySingle band by SDS-PAGE
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXW5807000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 45

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tetanus Toxin, Clostridium tetani - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Tetanus Toxin, Clostridium tetani - Calbiochem Certificates of Analysis

      TitleLot Number
      582243

      References

      Reference overview
      Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
      Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.

      Citations

      Title
    • Jerome Vicogne, et al. (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Procedings of the National Academy of Science 103, 14761-14766.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-January-2009 JSW
      DescriptionProduced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.
      FormLyophilized
      RTECSXW5807000
      PuritySingle band by SDS-PAGE
      Biological activityBinds GT1b ganglioside in a hemagglutination assay
      SolubilityPlease refer to the vial label for lot-specific reconstitution volume.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Toxicity Highly Toxic
      ReferencesMontecucco, C., et al. 1994. FEBS Lett. 346, 92.
      Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.
      Citation
    • Jerome Vicogne, et al. (2006) Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Procedings of the National Academy of Science 103, 14761-14766.