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648490 TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem

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Key Specifications Table

Empirical FormulaCAS #
C₁₆H₁₁Cl₃F₃N₃O₃ 1160514-60-2

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648490-10MG
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      Description
      OverviewA cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies.
      Catalogue Number648490
      Brand Family Calbiochem®
      SynonymsEthyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, CRAC Channel Inhibitor II, SB-360475
      References
      ReferencesSchleifier, H., et al. 2012. Br J Pharmacol In Press
      Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400.
      Product Information
      CAS number1160514-60-2
      FormDark brown solid
      Hill FormulaC₁₆H₁₁Cl₃F₃N₃O₃
      Chemical formulaC₁₆H₁₁Cl₃F₃N₃O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      648490

      References

      Reference overview
      Schleifier, H., et al. 2012. Br J Pharmacol In Press
      Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-March-2013 JSW
      SynonymsEthyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, CRAC Channel Inhibitor II, SB-360475
      DescriptionA cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies.
      FormDark brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1160514-60-2
      Chemical formulaC₁₆H₁₁Cl₃F₃N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (25 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchleifier, H., et al. 2012. Br J Pharmacol In Press
      Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400.