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613551 TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₉H₂₀N₄O₃S₂ 552309-42-9

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613551-5MG
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      Glass bottle 5 mg
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      Description
      OverviewAn aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
      Catalogue Number613551
      Brand Family Calbiochem®
      SynonymsANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
      References
      ReferencesDavis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
      Namkung, W., et al. 2011., J Biol Chem. in press.
      Namkung, W., et al. 2011., FASEB J. in press.
      Product Information
      CAS number552309-42-9
      FormOff-white powder
      Hill FormulaC₁₉H₂₀N₄O₃S₂
      Chemical formulaC₁₉H₂₀N₄O₃S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationTMEM16A Inhibitor, T16Ainh-A01, CAS 552309-42-9, acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM).
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TMEM16A Inhibitor, T16Ainh-A01 - Calbiochem Certificates of Analysis

      TitleLot Number
      613551

      References

      Reference overview
      Davis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
      Namkung, W., et al. 2011., J Biol Chem. in press.
      Namkung, W., et al. 2011., FASEB J. in press.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-September-2012 JSW
      SynonymsANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01
      DescriptionAn aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number552309-42-9
      Chemical formulaC₁₉H₂₀N₄O₃S₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml; clear, colorless solution)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDavis, A.J., et al. 2012 Br. J. Pharmacol.,/i> in press
      Namkung, W., et al. 2011., J Biol Chem. in press.
      Namkung, W., et al. 2011., FASEB J. in press.