616452 TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₇H₁₃N₅ 446859-33-2

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616452-2MG
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      Glass bottle 2 mg
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      Description
      OverviewA cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).
      Catalogue Number616452
      Brand Family Calbiochem®
      SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
      References
      ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.
      Product Information
      CAS number446859-33-2
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₇H₁₃N₅
      Chemical formulaC₁₇H₁₃N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetALKS binding
      Primary Target IC<sub>50</sub>23 nM
      Secondary targetALK 5 auto phosphorylation (IC₅₀ = 4 nM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      616452

      References

      Reference overview
      Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.

      Brochure

      Title
      TGF-b Signaling: Dual Role in Tumor Suppression and Oncogenesis (MilliporeSigma)

      Technical Info

      Title
      TGF-β Signaling: Dual Role in Tumor Suppression and Oncogenesis

      Citations

      Title
      Maherali N., and Hochedlinger, K., 2009. Current Biology 19, 1718.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
      DescriptionA cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number446859-33-2
      Chemical formulaC₁₇H₁₃N₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.
      CitationMaherali N., and Hochedlinger, K., 2009. Current Biology 19, 1718.