538001 MilliporeT-00127-HEV1 - CAS 900874-91-1 - Calbiochem
A potent & selective PI4KIIIb inhibitor that displays antienteroviral activity. Dose-dependently inhibits viral RNA replication and inactive towards HCV.
More>> A potent & selective PI4KIIIb inhibitor that displays antienteroviral activity. Dose-dependently inhibits viral RNA replication and inactive towards HCV. Less<<T-00127-HEV1 - CAS 900874-91-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II
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Overview
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Key Specifications Table
| CAS # | Empirical Formula |
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| 900874-91-1 | C₂₂H₂₉N₅O₃ |
Pricing & Availability
| Catalog Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 5.38001.0001 |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cell-permeable pyrazolopyrimidinamine derived enviroxime-like compound that displays anti-poliovirus activity with broad specificity for enteroviruses (EC50 = 0.77, 3.38, 2.5, 1.03 & >44 µM for PV, CVB3, HRVM, HCV 1b & HCV 2a, respectively). Dose-dependently inhibits viral RNA replication. Acts as a potent, selective, ATP-competitive and reversible inhibitor of PI4KIIIβ (IC50 = 150 nM) with poor affinity towards PI4KIIIα & PI4KIIα (IC50 = ~75 & ≥100 µM). Shown to cause PI4KIIIβ accumulation and reduce PI4P at the Golgi apparatus. Exhibits low cytotoxicity (CC50 > 50 µM in HeLa cells) and attractive PK profile in mice. PI4KIIIβ Inhibitor I, BF738735 (Cat. No. 533657) is also available. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 538001 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(3,4-Dimethoxyphenyl)-2,5-dimethyl-N-(2-morpholinoethyl)pyrazolo[1,5-a]pyrimidin-7-amine, PI4KIIIβ Inhibitor II |
| Description | T-00127-HEV1 |
| Product Information | |
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| CAS number | 900874-91-1 |
| Form | Off-whte solid |
| Hill Formula | C₂₂H₂₉N₅O₃ |
| Chemical formula | C₂₂H₂₉N₅O₃ |
| Reversible | Y |
| Quality Level | MQ200 |
| Applications |
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| Biological Information | |
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| Primary Target | PI4KIIIβ |
| Primary Target IC<sub>50</sub> | 150 nM for PI4KIII&beta |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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Documentation
T-00127-HEV1 - CAS 900874-91-1 - Calbiochem SDS
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References
| Reference overview |
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| Mejdrova, I., et al. 2015. J. Med. Chem. 58, In press. Spickler, C., et al. 2013. Antimicrob. Agents Chemother. 57, 3358. Sasaki, J., et al. 2012. EMBO J. 31, 754. Arita, M., et al. 2011. J. Virol. 85, 2364. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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