574711 Syk Inhibitor - CAS 622387-85-3 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₅N₃O₃S 622387-85-3

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574711-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC50 = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
      Catalogue Number574711
      Brand Family Calbiochem®
      SynonymsSpleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
      References
      ReferencesLai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.
      Product Information
      CAS number622387-85-3
      ATP CompetitiveY
      FormDeep orange solid
      Hill FormulaC₁₈H₁₅N₃O₃S
      Chemical formulaC₁₈H₁₅N₃O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSyk
      Primary Target IC<sub>50</sub>14 nM; EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3
      Purity≥97% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Syk Inhibitor - CAS 622387-85-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Syk Inhibitor - CAS 622387-85-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      574711

      References

      Reference overview
      Lai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      SynonymsSpleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
      DescriptionA cell-permeable, potent, reversible, and ATP-competitive Spleen Tyrosine Kinase (Syk) inhibitor (IC50 = 14 nM). Shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
      FormDeep orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number622387-85-3
      Chemical formulaC₁₈H₁₅N₃O₃S
      Structure formulaStructure formula
      Purity≥97% by HPLC (sum of two isomers)
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.