574662 Sigma-AldrichSurvivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem

The Survivin Inhibitor, YM155, also referenced under CAS 781661-94-7, controls the biological activity of Survivin.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Synonyms: Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor

Primary Target: Interleukin enhancer-binding factor 3 (ILF3/NF110)

Overview

Replacement Information

Key Specifications Table

Empirical Formula	CAS #
C₂₀H₁₉BrN₄O₃	781661-94-7

Pricing & Availability

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Description
Overview	A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC₅₀ = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
Catalogue Number	574662
Brand Family	Calbiochem®
Synonyms	Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor

References
References	Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434. Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198. Nakahara, T., et al. 2007, Cancer Res. 67, 8014.

Product Information
CAS number	781661-94-7
Form	Yellow solid
Hill Formula	C₂₀H₁₉BrN₄O₃
Reversible	Y
Structure formula Image

Applications

Biological Information
Primary Target	Interleukin enhancer-binding factor 3 (ILF3/NF110)
Primary Target IC<sub>50</sub>	540nM
Secondary target	Unknown
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Documentation

Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Survivin Inhibitor, YM155 - CAS 781661-94-7 - Calbiochem Certificates of Analysis

Title	Lot Number
574662	Enter Lot Number

References

Reference overview
Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434. Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198. Nakahara, T., et al. 2007, Cancer Res. 67, 8014.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	06-March-2017 JSW
Synonyms	Survivin Inhibitor I, Interleukin Enhancer-Binding Factor 3 Inhibitor
Description	A cell-permeable imidazolium derivative that suppresses survivin expression, blocks survivin promoter activity, and induces apoptosis in a variety of tumor cell lines (IC₅₀ = 540nM) in a dose-dependent manner. The main target of YM155 appears to be the interleukin enhancer-binding factor 3 (ILF3/NF110) with shorter C-terminal lengths associated with reduced binding. Exhibits potent anti-tumor effects without any severe systemic toxicity in murine models. Reported to induce tumor regression by suppressing intratumor survivin levels in PC3-xenograph tumor models (by 47% and 80% at 1 and 5 mg/kg, respectively.
Form	Yellow solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	781661-94-7
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (50 mg/ml)
Storage	-20°C Protect from light
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Nakamura, N., et al. 2012. Mol. Cell. Proteomics. 11, M111.0132434. Tolcher, A.W., et al. 2008, J. Clin. Oncol. 26, 5198. Nakahara, T., et al. 2007, Cancer Res. 67, 8014.