567430 Sodium Butyrate - CAS 156-54-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₄H₇O₂Na 156-54-7

Pricing & Availability

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567430-250MG
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      Glass bottle 250 mg
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      Description
      OverviewA short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells.
      Catalogue Number567430
      Brand Family Calbiochem®
      SynonymsButyric Acid, Na, NaB, HDAC Inhibitor V
      References
      ReferencesOu, H.C., et al. 1997. Neuroreport 8, 1375.
      Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
      Krupitza, G., et al. 1995. Carcinogenesis 16, 1199.
      Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31.
      Hague, A., et al. 1993. Int. J. Cancer 55, 498.
      Product Information
      CAS number156-54-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄H₇O₂Na
      Chemical formulaC₄H₇O₂Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationSodium Butyrate, CAS 156-54-7, is a short chain fatty acid that induces apoptosis in colon carcinoma cells by a p53-independent pathway. Down-regulates the activity of casein kinase II in HT29 cells.
      Biological Information
      Primary TargetInduce apoptosis
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSET6400000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Sodium Butyrate - CAS 156-54-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Sodium Butyrate - CAS 156-54-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      567430

      References

      Reference overview
      Ou, H.C., et al. 1997. Neuroreport 8, 1375.
      Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
      Krupitza, G., et al. 1995. Carcinogenesis 16, 1199.
      Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31.
      Hague, A., et al. 1993. Int. J. Cancer 55, 498.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      SynonymsButyric Acid, Na, NaB, HDAC Inhibitor V
      DescriptionA short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines in a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Downregulates the activity of serine/threonine protein kinase casein kinase II in HT29 cells.
      FormWhite solid
      CAS number156-54-7
      RTECSET6400000
      Chemical formulaC₄H₇O₂Na
      Structure formulaStructure formula
      Purity≥98% by titration
      SolubilityH₂O (2 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesOu, H.C., et al. 1997. Neuroreport 8, 1375.
      Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673.
      Krupitza, G., et al. 1995. Carcinogenesis 16, 1199.
      Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31.
      Hague, A., et al. 1993. Int. J. Cancer 55, 498.