566320 Sirtinol - CAS 410536-97-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₆H₂₂N₂O₂ 410536-97-9

Pricing & Availability

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566320-5MG
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable 2-hydroxy-1-naphthaldehyde derivative that acts as a specific and direct inhibitor of the sirtuin class of deacetylase activity with no affect on human HDAC1 (IC50 = 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively). Reported to inhibit Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM), and NAD-dependent histone deacetylase activity of purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 70 µM and 40 µM, respectively). A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566321) in DMSO is also available.
      Catalogue Number566320
      Brand Family Calbiochem®
      Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
      References
      ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
      Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.
      Product Information
      CAS number410536-97-9
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₆H₂₂N₂O₂
      Chemical formulaC₂₆H₂₂N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHuman HDAC1
      Primary Target IC<sub>50</sub>48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Sirtinol - CAS 410536-97-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Sirtinol - CAS 410536-97-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      566320

      References

      Reference overview
      Mai, A., et al. 2005. J. Med. Chem. 48, 7789.
      Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III
      DescriptionA cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number410536-97-9
      Chemical formulaC₂₆H₂₂N₂O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (1 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMai, A., et al. 2005. J. Med. Chem. 48, 7789.
      Grozinger, C.M., et al. 2001. J. Biol. Chem. 276, 38837.