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572888 SU1498 - Calbiochem

572888
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₂₅H₃₀N₂O₂

Pricing & Availability

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572888-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase. Also reduces the expression of ets-1, a transcription factor stimulated by VEGF. Has only a weak inhibitory effect on PDGF-receptor (IC50 >50 µM), EGF-receptor (IC50 >100 µM), and HER2 (IC50 >100 µM) kinases. Acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay and in an in vivo VEGF-induced permeability assay.
      Catalogue Number572888
      Brand Family Calbiochem®
      Synonyms(E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile, VEGFR Tyrosine Kinase Inhibitor VIII, VEGFR2 Kinase Inhibitor X
      References
      ReferencesArbiser, J.L., et al. 2000. Am. J. Pathol. 156, 1469.
      Strawn, L.M., et al. 1996. Cancer Res. 56, 3540.
      Product Information
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₂₅H₃₀N₂O₂
      Chemical formulaC₂₅H₃₀N₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSU1498, CAS 168835-82-3, is a potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM).
      Biological Information
      Primary TargetFlk-1 kinase
      Primary Target IC<sub>50</sub>700 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SU1498 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SU1498 - Calbiochem Certificates of Analysis

      TitleLot Number
      572888

      References

      Reference overview
      Arbiser, J.L., et al. 2000. Am. J. Pathol. 156, 1469.
      Strawn, L.M., et al. 1996. Cancer Res. 56, 3540.

      Citations

      Title
    • Marie Dance, et al. (2006) The adaptor protein gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase. Journal of Biological Chemistry 281, 23285-23295.
    • Ursula Mayr, et al. (2006) Accelerated Arteriosclerosis of Vein Grafts in Inducible NO Synthase-/- Mice Is Related to Decreased Endothelial Progenitor Cell Repair. Circulation Research 98, 412-420.
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms(E)-3-(3,5-Diisopropyl-4-hydroxyphenyl)-2-[(3-phenyl-n-propyl)amino-carbonyl]acrylonitrile, VEGFR Tyrosine Kinase Inhibitor VIII, VEGFR2 Kinase Inhibitor X
      DescriptionA potent, reversible, ATP-competitive and selective inhibitor of Flk-1 kinase (IC50 = 700 nM), a vascular endothelial growth factor (VEGF) receptor kinase. Has only a weak inhibitory effect on PDGF receptor (IC50 >50 µM), EGF-receptor (IC50 >100 µM), and HER-2 (IC50 >100 µM) kinases. Acts as an angiogenesis inhibitor as shown by its activity in the chorioallantoic membrane (CAM) assay and in an in vivo VEGF-induced permeability assay.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₃₀N₂O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesArbiser, J.L., et al. 2000. Am. J. Pathol. 156, 1469.
      Strawn, L.M., et al. 1996. Cancer Res. 56, 3540.
      Citation
    • Marie Dance, et al. (2006) The adaptor protein gab1 couples the stimulation of vascular endothelial growth factor receptor-2 to the activation of phosphoinositide 3-kinase. Journal of Biological Chemistry 281, 23285-23295.
    • Ursula Mayr, et al. (2006) Accelerated Arteriosclerosis of Vein Grafts in Inducible NO Synthase-/- Mice Is Related to Decreased Endothelial Progenitor Cell Repair. Circulation Research 98, 412-420.
    • Meenalakshmi M. Mariappan, et al. (2005) Phospholipase Cγ-Erk Axis in Vascular Endothelial Growth Factor-Induced Eukaryotic Initiation Factor 4E Phosphorylation and Protein Synthesis in Renal Epithelial Cells. Journal of Biological Chemistry 280, 28402-28411.
    • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.