Product Information
Applications
Biological Information
Primary TargetSTING
Primary Target K<sub>i</sub>4 nM, EC₅₀
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

STING Agonist, 2ʹ3ʹ-cGAMP - CAS 1441190-66-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Wu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
Zhang, X., et al. 2013. Mol. Cell. 51, 226.
Wu, J., et al. 2013. Science. 339, 26.

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature (EMD)
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage. (EMD)
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-December-2014 JSW
Synonymsc[G(2ʹ,5ʹ)pA(3ʹ,5ʹ)p], 2ʹ,5ʹ-3ʹ,5ʹ-cGAMP
DescriptionA cyclic-dinucleotide (cyclic-GMP-AMP) based compound that binds to the C-terminal domain of adaptor endoplasmic reticulum protein known as STING with high affinity (Kd = 4 nM) and induces the synthesis of interferon-b (IFN-b) in mammalian cells (EC50 = 20 nM). Shown to increase IFN-b production in M2-polarized macrophages associated with non-small cell lung carcinoma and enhances the expression of M1 markers iNOS and IL-12p40, while simultaneously reducing the expression of the M2 markers, Arg-1 and Fizz1. Exhibits about 300 fold greater affinity for STING than c-DiGMP, 3′,2′-cGAMP, and 3′,3′-cGAMP and about 75 fold greater affinity over 2′,2′-cGAMP.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1441190-66-4
Chemical formulaC₂₀H₂₄N₁₀O₁₃P₂ (free acid)
Purity≥98% by HPLC
SolubilityH₂O
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWu, X., et al. 2014. Nuc. Aci. Res. 42, 8243.
Zhang, X., et al. 2013. Mol. Cell. 51, 226.
Wu, J., et al. 2013. Science. 339, 26.

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Categories

Life Science Research > Inhibitors and Biochemicals > Biochemicals > Lipids