573132 STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

573132
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₉H₂₇F₅N₂O₆S 1334493-07-0

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573132-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
      Catalogue Number573132
      Brand Family Calbiochem®
      Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
      References
      ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
      Product Information
      CAS number1334493-07-0
      FormWhite powder
      Hill FormulaC₂₉H₂₇F₅N₂O₆S
      Chemical formulaC₂₉H₂₇F₅N₂O₆S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSTAT3 Inhibitor XVIII, BP-1-102, CAS 1334493-07-0, binds to the three subpockets of STAT3 SH2 domain and blocks STAT3 phosphorylation, dimerization, and DNA-binding activity.
      Biological Information
      Primary TargetStat3
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem Certificates of Analysis

      TitleLot Number
      573132

      References

      Reference overview
      Zhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2013 JSW
      Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
      DescriptionA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1334493-07-0
      Chemical formulaC₂₉H₂₇F₅N₂O₆S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.