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567417 SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₁H₈Cl₂N₂O 41931-13-9

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567417-10MG
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      Glass bottle 10 mg
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      Description
      OverviewA 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
      Catalogue Number567417
      Brand Family Calbiochem®
      Synonymslung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
      References
      ReferencesSomwar, R., et al. 2011, PNAS in press.
      Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176
      Product Information
      CAS number41931-13-9
      FormWhite solid
      Hill FormulaC₁₁H₈Cl₂N₂O
      Chemical formulaC₁₁H₈Cl₂N₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      567417

      References

      Reference overview
      Somwar, R., et al. 2011, PNAS in press.
      Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      Synonymslung cancer screen 1, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, 4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, Superoxide dismutase 1 inhibitor
      DescriptionA 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50 = 1.07 µM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50 = 200 nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6 min in human liver microsomes.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number41931-13-9
      Chemical formulaC₁₁H₈Cl₂N₂O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/mlg; clear, colorless solution)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSomwar, R., et al. 2011, PNAS in press.
      Somwar, R., et al. 2009. J. Biomol. Screen 14, 1176