566326 SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₃H₁₃Cl₂N₃O₂ 304896-21-7

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566326-5MG
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      Description
      OverviewA cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
      Catalogue Number566326
      Brand Family Calbiochem®
      SynonymsSIRT2 Inhibitor I, Inactive Control
      References
      ReferencesOuterio, T.F., et al. 2007. Science 317, 516.
      Product Information
      CAS number304896-21-7
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₂₃H₁₃Cl₂N₃O₂
      Chemical formulaC₂₃H₁₃Cl₂N₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSirtuin 3
      Primary Target IC<sub>50</sub>>5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SIRT2 Inhibitor, Inactive Control, AGK7 - CAS 304896-21-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      566326

      References

      Reference overview
      Outerio, T.F., et al. 2007. Science 317, 516.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-December-2007 JSW
      SynonymsSIRT2 Inhibitor I, Inactive Control
      DescriptionA cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number304896-21-7
      Chemical formulaC₂₃H₁₃Cl₂N₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesOuterio, T.F., et al. 2007. Science 317, 516.