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566324 SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₂₃H₁₃Cl₂N₃O₂ 304896-28-4

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566324-5MG
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      Description
      OverviewA cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
      Catalogue Number566324
      Brand Family Calbiochem®
      Synonyms2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
      References
      ReferencesOuterio, T.F., et al. 2007. Science 317, 516.
      Product Information
      CAS number304896-28-4
      FormYellow solid
      Hill FormulaC₂₃H₁₃Cl₂N₃O₂
      Chemical formulaC₂₃H₁₃Cl₂N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      566324

      References

      Reference overview
      Outerio, T.F., et al. 2007. Science 317, 516.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-March-2008 RFH
      Synonyms2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
      DescriptionA cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number304896-28-4
      Chemical formulaC₂₃H₁₃Cl₂N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (2.5 mg/ml). Slight warming may be required for complete solubilization.
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesOuterio, T.F., et al. 2007. Science 317, 516.