508119 SB 399885 Hydrochloride - CAS 402713-80-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885

Primary Target: 5-HT₆
508119
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₁Cl₂N₃O₄S·HCl 402713-80-8

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.08119.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
          Catalogue Number508119
          Brand Family Calbiochem®
          Synonyms5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885
          References
          ReferencesWesolowska, A. et al. 2007. Pharmacol Rep. 59, 664.
          Li, Z. et al. 2007. Brain Res. 1134, 70.
          Hirst, et al. 2006. Eur. J. Pharm. 553, 109.
          Routledge, C. et al. 2000. Br. J. Pharmacol. 130, 1606.
          Product Information
          CAS number402713-80-8
          FormWhite solid
          Hill FormulaC₁₈H₂₁Cl₂N₃O₄S·HCl
          Chemical formulaC₁₈H₂₁Cl₂N₃O₄S·HCl
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target5-HT₆
          Primary Target K<sub>i</sub>1 nM
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SB 399885 Hydrochloride - CAS 402713-80-8 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Wesolowska, A. et al. 2007. Pharmacol Rep. 59, 664.
          Li, Z. et al. 2007. Brain Res. 1134, 70.
          Hirst, et al. 2006. Eur. J. Pharm. 553, 109.
          Routledge, C. et al. 2000. Br. J. Pharmacol. 130, 1606.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-October-2013 JSW
          Synonyms5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885
          DescriptionA high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
          FormWhite solid
          CAS number402713-80-8
          Chemical formulaC₁₈H₂₁Cl₂N₃O₄S·HCl
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mM) or H₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesWesolowska, A. et al. 2007. Pharmacol Rep. 59, 664.
          Li, Z. et al. 2007. Brain Res. 1134, 70.
          Hirst, et al. 2006. Eur. J. Pharm. 553, 109.
          Routledge, C. et al. 2000. Br. J. Pharmacol. 130, 1606.