Product Information
Applications
Biological Information
Primary Targetp38β
Primary Target IC<sub>50</sub>350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
Primary Target K<sub>i</sub>16 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem Certificates of Analysis

TitleLot Number
559393

Citations

Title
  • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
  • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision19-April-2011 RFH
    Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
    DescriptionA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
    FormAmber solid
    CAS number350228-36-3
    Chemical formulaC₂₀H₁₄FN₃O · HCl
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO or slightly soluble in H₂O (0.5 mg/ml)
    Storage -20°C
    Hygroscopic
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
    Toxicity Standard Handling
    Citation
  • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
  • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
  • Related Products & Applications

    Alternative Products

    Catalog Number Description  
    559388 SB 202190 - CAS 152121-30-7 - Calbiochem Show Pricing & Availability

    Categories

    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors