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472804 S-Methyl-L-thiocitrulline, Dihydrochloride - CAS 209589-59-3 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
209589-59-3C₇H₁₅N₃O₂S · 2HCl

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472804-10MG
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      Description
      OverviewA cell-permeable inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).
      Catalogue Number472804
      Brand Family Calbiochem®
      SynonymsNδ-(S-Methyl)isothioureido-L-ornithine
      References
      ReferencesKrishnaswamy, N., et al. 1995. J. Biol. Chem. 270, 11103.
      Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
      Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem. 37, 885.
      Product Information
      CAS number209589-59-3
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₇H₁₅N₃O₂S · 2HCl
      Chemical formulaC₇H₁₅N₃O₂S · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRat neuronal nitric oxide synthase
      Primary Target IC<sub>50</sub>300 nM for rat neuronal nitric oxide synthase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      S-Methyl-L-thiocitrulline, Dihydrochloride - CAS 209589-59-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      472804

      References

      Reference overview
      Krishnaswamy, N., et al. 1995. J. Biol. Chem. 270, 11103.
      Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
      Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem. 37, 885.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-January-2017 JSW
      SynonymsNδ-(S-Methyl)isothioureido-L-ornithine
      DescriptionA cell-permeable, inhibitor of nitric oxide synthase that exhibits about 17-fold greater selectivity for rat neuronal nitric oxide synthase (IC50 = 300 nM) compared to the endothelial enzyme (IC50 = 5.4 µM).
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number209589-59-3
      Chemical formulaC₇H₁₅N₃O₂S · 2HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Toxicity Standard Handling
      ReferencesKrishnaswamy, N., et al. 1995. J. Biol. Chem. 270, 11103.
      Furfine, E.S., et al. 1994. J. Biol. Chem. 269, 26677.
      Narayanan, K., and Griffith, O.W. 1994. J. Med. Chem. 37, 885.