Product Information
Applications
Biological Information
Primary TargetGrup I and II mGlu receptors
Primary Target IC<sub>50</sub>40 and 15 →M for mGlu₁ and mGlu₂, respectively.
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

(S)-MCPG - CAS 150145-89-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Fano, S., et al. 2012. Eur. J. Neurosci. 36, 3628.
Wang, W., et al. 2012. J. Physiol. 590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646. Schoepp, D.D., et al. 1999.
Neuropharmacol. 38, 1431.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonyms(S)-α-Methyl-4-carboxyphenylglycine, Group I/II mGlu Antagonist, (S)-MCPG
DescriptionA non-selective antagonist for group I/II mGlu receptors (minimal values of IC50 reported = 40 and 15 µM for mGlu1 and mGlu2, respectively). Often used as an agent to differentiate excitatory neurotransmissions mediated by glutamate from other neurotransmitters (i.e. dopamine, acetylcholine, and GABA in early brain development). A common component of cocktails for blocking glutamate transmission in brain slice preparation.
FormWhite solid
CAS number150145-89-4
Chemical formulaC₁₀H₁₁NO₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (10 mM) or DMSO (10 mM)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFano, S., et al. 2012. Eur. J. Neurosci. 36, 3628.
Wang, W., et al. 2012. J. Physiol. 590, 3743.
Cortes, C., et al. 2013. Synapse. DOI: 10.1002/syn.21646. Schoepp, D.D., et al. 1999.
Neuropharmacol. 38, 1431.

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Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Antagonists > Glutamate Receptor Antagonists