509707 Sigma-Aldrich(S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem

A potent and selective agonist for GluK1-containing kainate receptors (EC₅₀ = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively). Does not interact with GluK2, GluK6, and GluK7 receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
References
Data Sheet

Synonyms: (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine

Primary Target: GluK1

Recommended Products

Overview

Replacement Information

Key Specifications Table

Empirical Formula	CAS #
C₇H₈IN₃O₄	140187-25-3

Pricing & Availability

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Description
Overview	A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC₅₀ = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC₅₀ = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC₅₀ = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis. Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number	509707
Brand Family	Calbiochem®
Synonyms	(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine

References
References	Bhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307. Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788. Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26. Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.

Product Information
CAS number	140187-25-3
Form	White solid
Hill Formula	C₇H₈IN₃O₄
Chemical formula	C₇H₈IN₃O₄
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	GluK1
Purity	≥98% by HPLC

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity	Standard Handling
Storage	+2°C to +8°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Documentation

(S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

References

Reference overview
Bhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307. Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788. Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26. Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	28-February-2014 JSW
Synonyms	(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
Description	A potent agonist highly selective for GluK1-containing subtype kainate receptors (EC₅₀ = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC₅₀ = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC₅₀ = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.
Form	White solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	140187-25-3
Chemical formula	C₇H₈IN₃O₄
Structure formula
Purity	≥98% by HPLC
Solubility	1N NaOH (25 mM)
Storage	+2°C to +8°C Protect from light
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Bhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307. Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788. Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26. Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.