509707 (S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem

A potent and selective agonist for GluK1-containing kainate receptors (EC₅₀ = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively). Does not interact with GluK2, GluK6, and GluK7 receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine

Primary Target: GluK1
509707
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₇H₈IN₃O₄ 140187-25-3

      Pricing & Availability

      Catalog Number AvailabilityPackaging Qty/Pack Price Quantity
      5.09707.0001
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          		 Glass bottle 10 mg
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          Description
          OverviewA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number509707
          Brand Family Calbiochem®
          Synonyms(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
          References
          ReferencesBhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
          Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
          Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
          Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.
          Product Information
          CAS number140187-25-3
          FormWhite solid
          Hill FormulaC₇H₈IN₃O₄
          Chemical formulaC₇H₈IN₃O₄
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetGluK1
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (S)-5-Iodowillardiine - CAS 140187-25-3 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          References

          Reference overview
          Bhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
          Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
          Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
          Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-February-2014 JSW
          Synonyms(S)-α-Amino-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid, (S)-2-amino-3-(5-iodo-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)propanoic acid, Iodowillardiine
          DescriptionA potent agonist highly selective for GluK1-containing subtype kainate receptors (EC50 = 0.06 and 0.21 µM for GluK1/K5 and GluK1, respectively) over GluK2-containing subtypes (EC50 = 0.47 and 30 µM for GluK1/K2 and GluK2/K5 respectively). Does not interact with GluK2, GluK6, and GluK7 receptors. Low affinity to AMPA receptors (EC50 = 1.5 and 33.6 µM for GluA2 and GluA1 respectively). Has been used in assessing the functional roles of GluK1-containing subtype kainate receptors in neuropathic pains, apoptosis, and necrosis.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number140187-25-3
          Chemical formulaC₇H₈IN₃O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          Solubility1N NaOH (25 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBhangoo, K., et al. 2013. Mol. Pharmacol. 83, 307.
          Moldrich, X., et al. 2000. J. Neurosci. Res. 59, 788.
          Chittajallu, R., et al. 1999. Trends Pharmacol. Sci. 20, 26.
          Swanson, T., et al. 1998. Mol. Pharmacol. 53, 942.