504375 (S)-3,4-DCPG - CAS 201730-11-2 - Calbiochem

(S)-3,4-DCPG - CAS 201730-11-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S)-3,4-Dicarboxyphenylglycine

Primary Target: mGlu8a
504375
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Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₀H₉NO₆ 201730-11-2

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      Description
      OverviewA highly potent and selective mGlu8a agonist (EC50 = 31 nM, a value of 100-fold lower those for mGlu1-7). Negligible activation at NMDA and kainate receptors. Exerts an amygdala mediated angiogenic-effect and evokes neuronal activities in stress-related brain areas following systemic administration in mice in vivo. A potent anticonvulsant in mice in vivo.
      Catalogue Number504375
      Brand Family Calbiochem®
      Synonyms(S)-3,4-Dicarboxyphenylglycine
      References
      ReferencesDobia, A., et al. 2013. Neuropharmacology. 66, 274.
      Thomas, N., et al. 1997. Eur. J. Pharmacol. 338 , 111.
      Moldrich, R., et al. 2001. Neuropharmacology. 40, 732.
      Thomas, N., et al, 2001. Neuropharmacology. 40, 311.
      Linden, A., et al, 2003. Neuropharmacology. 45, 473.
      Product Information
      CAS number201730-11-2
      FormWhite solid
      Hill FormulaC₁₀H₉NO₆
      Chemical formulaC₁₀H₉NO₆
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetmGlu8a
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Dobia, A., et al. 2013. Neuropharmacology. 66, 274.
      Thomas, N., et al. 1997. Eur. J. Pharmacol. 338 , 111.
      Moldrich, R., et al. 2001. Neuropharmacology. 40, 732.
      Thomas, N., et al, 2001. Neuropharmacology. 40, 311.
      Linden, A., et al, 2003. Neuropharmacology. 45, 473.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms(S)-3,4-Dicarboxyphenylglycine
      DescriptionA highly potent and selective mGlu8a agonist (EC50 = 31 nM, a value of 100-fold lower those for mGlu1-7). Negligible activation at NMDA and kainate receptors. Exerts an amygdala mediated angiogenic-effect and evokes neuronal activities in stress-related brain areas following systemic administration in mice in vivo. A potent anticonvulsant in mice in vivo.
      FormWhite solid
      CAS number201730-11-2
      Chemical formulaC₁₀H₉NO₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage +15°C to +30°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDobia, A., et al. 2013. Neuropharmacology. 66, 274.
      Thomas, N., et al. 1997. Eur. J. Pharmacol. 338 , 111.
      Moldrich, R., et al. 2001. Neuropharmacology. 40, 732.
      Thomas, N., et al, 2001. Neuropharmacology. 40, 311.
      Linden, A., et al, 2003. Neuropharmacology. 45, 473.