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Description
Overview
A highly potent and selective mGlu8a agonist (EC50 = 31 nM, a value of 100-fold lower those for mGlu1-7). Negligible activation at NMDA and kainate receptors. Exerts an amygdala mediated angiogenic-effect and evokes neuronal activities in stress-related brain areas following systemic administration in mice in vivo. A potent anticonvulsant in mice in vivo.
Catalogue Number
504375
Brand Family
Calbiochem®
Synonyms
(S)-3,4-Dicarboxyphenylglycine
References
References
Dobia, A., et al. 2013. Neuropharmacology. 66, 274. Thomas, N., et al. 1997. Eur. J. Pharmacol. 338 , 111. Moldrich, R., et al. 2001. Neuropharmacology. 40, 732. Thomas, N., et al, 2001. Neuropharmacology. 40, 311. Linden, A., et al, 2003. Neuropharmacology. 45, 473.
Product Information
CAS number
201730-11-2
Form
White solid
Hill Formula
C₁₀H₉NO₆
Chemical formula
C₁₀H₉NO₆
Structure formula Image
Applications
Biological Information
Primary Target
mGlu8a
Purity
≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
+15°C to +30°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Documentation
References
Reference overview
Dobia, A., et al. 2013. Neuropharmacology. 66, 274. Thomas, N., et al. 1997. Eur. J. Pharmacol. 338 , 111. Moldrich, R., et al. 2001. Neuropharmacology. 40, 732. Thomas, N., et al, 2001. Neuropharmacology. 40, 311. Linden, A., et al, 2003. Neuropharmacology. 45, 473.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
12-July-2013 JSW
Synonyms
(S)-3,4-Dicarboxyphenylglycine
Description
A highly potent and selective mGlu8a agonist (EC50 = 31 nM, a value of 100-fold lower those for mGlu1-7). Negligible activation at NMDA and kainate receptors. Exerts an amygdala mediated angiogenic-effect and evokes neuronal activities in stress-related brain areas following systemic administration in mice in vivo. A potent anticonvulsant in mice in vivo.
Form
White solid
CAS number
201730-11-2
Chemical formula
C₁₀H₉NO₆
Structure formula
Purity
≥98% by HPLC
Solubility
H₂O (100 mM)
Storage
Protect from light
+15°C to +30°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Dobia, A., et al. 2013. Neuropharmacology. 66, 274. Thomas, N., et al. 1997. Eur. J. Pharmacol. 338 , 111. Moldrich, R., et al. 2001. Neuropharmacology. 40, 732. Thomas, N., et al, 2001. Neuropharmacology. 40, 311. Linden, A., et al, 2003. Neuropharmacology. 45, 473.