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531547 RyR1 Modulator, CCDI - Calbiochem

A cell-permeable compound that selectively and reversibly binds to the cytoplasmic domain of mammalian RyR1 and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC₅₀ = 6 µM).

RyR1 Modulator, CCDI - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ryanodine Receptor 1 Modulator

Primary Target: RyR1
531547
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Overview

Replacement Information

Key Specifications Table

Empirical Formula
C₁₈H₂₅N₃O

Pricing & Availability

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      Description
      OverviewA cell-permeable pyrrolo[1,2-c]imidazolone derived compound that selectively and preferentially binds to the cytoplasmic domain of mammalian ryanodine receptor 1 (RyR1) in a reversible manner and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC50 = 6 µM). Increases the open probability (Po) of RyR1 without affecting RyR2, RyR3, or the IP3R. Does not alter RyR1 conductance or the Kd for 3H-ryanodine binding to RyR1 in any significant manner (~4 nM vs 4.2 nM with and without CCDI in the medium). Induces Ca2+ transients in C2C12 skeletal myotubes, but does not alter Ca2+ transients in rat ventricular myocytes.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number531547
      Brand Family Calbiochem®
      SynonymsRyanodine Receptor 1 Modulator
      References
      ReferencesTian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₈H₂₅N₃O
      Chemical formulaC₁₈H₂₅N₃O
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRyR1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      RyR1 Modulator, CCDI - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Tian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2014 JSW
      SynonymsRyanodine Receptor 1 Modulator
      DescriptionA cell-permeable pyrrolo[1,2-c]imidazolone derived compound that selectively and preferentially binds to the cytoplasmic domain of mammalian ryanodine receptor 1 (RyR1) in a reversible manner and potentiates Ca2+-dependent binding of [3H]-ryanodine to RyR1(EC50 = 6 µM). Increases the open probability (Po) of RyR1 without affecting RyR2, RyR3, or the IP3R. Does not alter RyR1 conductance or the Kd for 3H-ryanodine binding to RyR1 in any significant manner (~4 nM vs 4.2 nM with and without CCDI in the medium). Induces Ca2+ transients in C2C12 skeletal myotubes, but does not alter Ca2+ transients in rat ventricular myocytes.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₂₅N₃O
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTian, C., et al. 2014. Br. J. Pharmcol. 171, 4097.