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555558 Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₈H₁₃ClF₆N₂O₃ 285986-88-1

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555558-25MG
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      Glass bottle 25 mg
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      Description
      OverviewA cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 ≤300 nM) and block RhoC/ Gα12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM.
      Catalogue Number555558
      Brand Family Calbiochem®
      SynonymsN-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
      References
      ReferencesLundquist, M.R., et al. 2014. Cell 156, 563..
      Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.
      Product Information
      CAS number285986-88-1
      FormWhite solid
      Hill FormulaC₁₈H₁₃ClF₆N₂O₃
      Chemical formulaC₁₈H₁₃ClF₆N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Rho/SRF Pathway Inhibitor, CCG-1423 - CAS 285986-88-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      555558

      References

      Reference overview
      Lundquist, M.R., et al. 2014. Cell 156, 563..
      Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-January-2014 JSW
      SynonymsN-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I
      DescriptionA cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC50 ≤300 nM) and block RhoC/ Gα12-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a Ki of 1.5 µM.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number285986-88-1
      Chemical formulaC₁₈H₁₃ClF₆N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLundquist, M.R., et al. 2014. Cell 156, 563..
      Evelyn, C.R., et al. 2007. Mol. Cancer Ther. 6, 2249.