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HTS217RTA Ready-to-Assay™ GPR39 Orphan Receptor Frozen Cells

Human GPR39 GPCR frozen cells for Calcium Flux FLIPR Assays.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Host Cell: HEK293 Entrez Gene Number: NM_001508
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HTS217RTA
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      Overview

      Replacement Information

      Special Offers

      This product requires a User Agreement (Label License). Please see product datasheet for further information

      Key Specifications Table

      SpeciesHost CellsProtein Target
      Human HEK293GPR39
      Description
      Catalogue NumberHTS217RTA
      Trade Name
      • Ready-to-Assay
      DescriptionReady-to-Assay™ GPR39 Orphan Receptor Frozen Cells
      Background InformationMillipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.

      GPR39 is a 7TM protein related to the G protein-coupled receptors for the gastrointestinal peptides ghrelin and motilin. Although GPR39 has been reported to be a receptor for the peptide obestatin, GPR39 has been more thoroughly characterized as a receptor for Zn2+, as well as Cu2+ and Ni2+ (Holst et al., 2007; Yasuda et al., 2007). Studies on GPR39-null mice implicate GPR39 in the control of insulin secretion, thereby indicating its potential as a target for treatment of diabetes (Holst et al., 2009; Tremblay et al., 2009). Millipore’s cloned human GPR39-expressing cell line is made in the HEK293 host, which supports high levels of recombinant GPR39 expression on the cell surface for functional detection via the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists and modulators at GPR39.
      References
      Product Information
      Components
      • Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
      • Fifty (50) mL of Media Component.
      Detection methodFluorescent
      Quality LevelMQ100
      Applications
      ApplicationHuman GPR39 GPCR frozen cells for Calcium Flux FLIPR Assays.
      Key Applications
      • Calcium Flux Assays
      Biological Information
      Entrez Gene Number
      GPCR ClassA
      Host CellsHEK293
      Protein TargetGPR39
      Target Sub-FamilyOrphan
      Cell Line Type
      • GPCR Cell Lines
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges MilliporeSigma to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size1 kit
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalog Number GTIN
      HTS217RTA 04053252422225

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      Categories

      Life Science Research > Cell Culture and Systems > Cell Lines > GPCR Frozen Cells
      Life Science Research > Drug Discovery and Development > GPCR Cell Lines & Assays > GPCR Frozen Cells