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553509 Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

Overview

Replacement Information

Key Specifications Table

Empirical FormulaCAS #
C₁₆H₂₀N₄O₃ 171927-40-5

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553509-10MG
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      Description
      OverviewA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
      Catalogue Number553509
      Brand Family Calbiochem®
      Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
      References
      ReferencesHuber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
      Product Information
      CAS number171927-40-5
      ATP CompetitiveN
      FormLight-yellow solid
      Hill FormulaC₁₆H₂₀N₄O₃
      Chemical formulaC₁₆H₂₀N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRas/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.
      Biological Information
      Primary TargetRas/Rac
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      553509

      References

      Reference overview
      Huber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2014 JSW
      Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
      DescriptionA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
      FormLight-yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number171927-40-5
      Chemical formulaC₁₆H₂₀N₄O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHuber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.