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553511 Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem

Overview

Replacement Information

Key Specifications Table

CAS #Empirical Formula
1090893-12-1C₂₀H₂₁N₃O₅S

Pricing & Availability

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553511-10MG
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      Description
      OverviewA cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). Also available in InSolution™ format (Cat. No. 553512).
      Catalogue Number553511
      Brand Family Calbiochem®
      Synonyms3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982
      References
      ReferencesFerri, N., et al. 2009. J. Med. Chem. 52, 4087.
      Product Information
      CAS number1090893-12-1
      FormOff-white solid
      Hill FormulaC₂₀H₂₁N₃O₅S
      Chemical formulaC₂₀H₂₁N₃O₅S
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥93% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Rac1 Inhibitor II - CAS 1090893-12-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      553511

      References

      Reference overview
      Ferri, N., et al. 2009. J. Med. Chem. 52, 4087.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide, Z62954982
      DescriptionAA cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1090893-12-1
      Chemical formulaC₂₀H₂₁N₃O₅S
      Purity≥93% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesFerri, N., et al. 2009. J. Med. Chem. 52, 4087.