Product Information
Applications
Biological Information
Primary TargetmGlu₈
Purity≥97% by NMR
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

References

Reference overview
Gasparini, F., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1678.
Palucha, A., et al. 2004. Neuropharmacology. 46, 151.
Bigge, C., et al. 1989. J. Med. Chem. 32, 1580.
Schoepp, D., et al. 1999. Neuropharmacology. 38, 1431.

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-June-2013 JSW
Synonyms(RS)-4-Phosphonophenylglycine
DescriptionA potent and subtype-selective agonist for group III metabotropic glutamate receptors. 25-fold higher selectivity for mGlu8 (EC50 =0.21 µM ) than for other group III mGlu receptors (EC50 = 5.2, 4.7, and 185 µM for mGlu4,6,7, respectively). Widely used as anticonvulsant, antidepressant, anxiolytic, and neuroprotective agent in research.
FormWhite powder
CAS number120667-15-4
Chemical formulaC₈H₁₀NO₅P
Structure formulaStructure formula
Purity≥97% by NMR
SolubilityDMSO (2 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGasparini, F., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1678.
Palucha, A., et al. 2004. Neuropharmacology. 46, 151.
Bigge, C., et al. 1989. J. Med. Chem. 32, 1580.
Schoepp, D., et al. 1999. Neuropharmacology. 38, 1431.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Agonists > Glutamate Receptor Agonists