504395 (RS)-PPG - CAS 120667-15-4 - Calbiochem

504395
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Key Specifications Table

Empirical FormulaCAS #
C₈H₁₀NO₅P 120667-15-4

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      Glass bottle 5 mg
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      Description
      OverviewA potent and subtype-selective agonist for group III metabotropic glutamate receptors. 25-fold higher selectivity for mGlu8 (EC50 =0.21 µM ) than for other group III mGlu receptors (EC50 = 5.2, 4.7, and 185 µM for mGlu4,6,7, respectively). Widely used as anticonvulsant, antidepressant, anxiolytic, and neuroprotective agent in research.
      Catalogue Number504395
      Brand Family Calbiochem®
      Synonyms(RS)-4-Phosphonophenylglycine
      References
      ReferencesGasparini, F., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1678.
      Palucha, A., et al. 2004. Neuropharmacology. 46, 151.
      Bigge, C., et al. 1989. J. Med. Chem. 32, 1580.
      Schoepp, D., et al. 1999. Neuropharmacology. 38, 1431.
      Product Information
      CAS number120667-15-4
      FormWhite powder
      Hill FormulaC₈H₁₀NO₅P
      Chemical formulaC₈H₁₀NO₅P
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₈
      Purity≥97% by NMR
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      References

      Reference overview
      Gasparini, F., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1678.
      Palucha, A., et al. 2004. Neuropharmacology. 46, 151.
      Bigge, C., et al. 1989. J. Med. Chem. 32, 1580.
      Schoepp, D., et al. 1999. Neuropharmacology. 38, 1431.

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer (EMD)
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonyms(RS)-4-Phosphonophenylglycine
      DescriptionA potent and subtype-selective agonist for group III metabotropic glutamate receptors. 25-fold higher selectivity for mGlu8 (EC50 =0.21 µM ) than for other group III mGlu receptors (EC50 = 5.2, 4.7, and 185 µM for mGlu4,6,7, respectively). Widely used as anticonvulsant, antidepressant, anxiolytic, and neuroprotective agent in research.
      FormWhite powder
      CAS number120667-15-4
      Chemical formulaC₈H₁₀NO₅P
      Structure formulaStructure formula
      Purity≥97% by NMR
      SolubilityDMSO (2 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGasparini, F., et al. 1999. J. Pharmacol. Exp. Ther. 289, 1678.
      Palucha, A., et al. 2004. Neuropharmacology. 46, 151.
      Bigge, C., et al. 1989. J. Med. Chem. 32, 1580.
      Schoepp, D., et al. 1999. Neuropharmacology. 38, 1431.