Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
If you have chosen panel analytes and then choose a premix or single plex kit, you will lose that customization.
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48-602MAG
Buffer Detection Kit for Magnetic Beads
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Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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508147
Sigma-AldrichRS 127445 Hydrochloride - CAS 199864-86-3 - Calbiochem
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Description
Overview
A selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
Catalogue Number
508147
Brand Family
Calbiochem®
References
References
Sharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther.22, 389. Bonhaus, D. W. et al. 1999. Br. J. Pharmacol.127, 1075. Bonhaus, D. W. et al. 1999. Br. J. Pharmacol.127, 1075.
Product Information
CAS number
199864-86-3
Form
Off-white solid
Hill Formula
C₁₇H₁₆FN₃·HCl
Chemical formula
C₁₇H₁₆FN₃·HCl
Structure formula Image
Applications
Biological Information
Primary Target
5-HT2B
Purity
≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity
Standard Handling
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Identification Number
Catalog Number
GTIN
5.08147.0001
4055977242850
Documentation
References
Reference overview
Sharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther.22, 389. Bonhaus, D. W. et al. 1999. Br. J. Pharmacol.127, 1075. Bonhaus, D. W. et al. 1999. Br. J. Pharmacol.127, 1075.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
25-October-2013 JSW
Description
A selective, high affinity , orally bioavailable 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi = 9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites including the closely related 5-HT2A and 5-HT2C receptors. In isolated human cells, RS-127445 exbhited an IC50 greater than 10 µM.
Form
Off-white solid
CAS number
199864-86-3
Chemical formula
C₁₇H₁₆FN₃·HCl
Structure formula
Purity
≥98% by HPLC
Solubility
DMSO (100 mM) or Ethanol (100 mM)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Sharif, N. A. et al. 2006. J. Ocul. Pharmacol. Ther.22, 389. Bonhaus, D. W. et al. 1999. Br. J. Pharmacol.127, 1075. Bonhaus, D. W. et al. 1999. Br. J. Pharmacol.127, 1075.
